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1 vs.14.1months, P 0.001). Accordingly, there was a significantly difference in terms of overall survival time between two groups (hazard ratio 3.04; 95% confidence interval 1.58-5.85, P 0.001). Multivariate regression suggested that NKD2 was independently prognostic factors in terms of progression-free survival (hazard ratio 2.91; 95% confidence interval 1.61-5.27, P 0.001) and overall survival (hazard ratio 3.6; 95% confidence interval 1.80-7.21, P 0.001). In vitro studies further demonstrated that NKD2 suppressed
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