https://www.selleckchem.com/pr....oducts/pkm2-inhibito
1 N HCl, pH 1.2, and ~100% in phosphate buffer, pH 7.4) in comparison to physical mixture (~ 30% and ~ 80%) and ACE (~18% and ~50%) after 60 min, respectively. Stability studies of cocrystal tablets for 3 months indicated a stable formulation. Pharmacokinetic studies were performed by using rabbit model. The AUC0-∞ (37.87±1.3 μgh/ml) and Cmax (6.94±2.94 μg/ml) of the selected cocrystal C1 prepared by SAG were significantly enhanced (p less then 0.05) and were ~3.43 and ~1.63-fold higher than that of ACE. In conclusion
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