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1 mmHg, = 0.03. PaCO higher than 59 mmHg after HFNC for 24 h was identified as an independent risk factor for treatment failure [OR 1.078, 95% CI 1.006-1.154, = 0.032]. In AECOPD patients with acute compensated hypercapnic respiratory failure, HFNC improved the prognosis compared with COT. Therefore, HFNC might be considered for first-line oxygen therapy in select patients. ClinicalTrials.Gov NCT02439333. ClinicalTrials.Gov NCT02439333. To identify associated factors of having at least one of the airflow limitation, chronic cough/phle
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