https://zosuquidarmodulator.co....m/decentralized-mult
The style of inhibitors, focusing on active-inactive conformational transitions associated with enzyme, can be aided by comprehending the interplay between structure and dynamics . Here, we report the results of mutations in the catalytic triad on structure, conformational gating and characteristics of hMGL by combining kinetics, NMR, and HDX-MS information with metadynamics simulations. We found that point mutations alter fragile conformational equilibria
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