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Medications and Therapy For ADHD Combining medication and therapy can help to manage ADHD. Medications treat the brain, while therapy helps people learn strategies and cope. The stimulants like methylphenidate and Lisdexamfetamine boost the levels of two chemicals that transmit messages between cells in the brain. This increases attention, impulse control and motivation. Stimulants can cause side effects such as loss of appetite, trouble sleeping, and an increased heart rate and blood pressure. Stimulants Stimulants are typically