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How to Choose the Best ADHD Medication for Adults Stimulant medications like methylphenidate and amphetamine work by boosting and balancing the levels of brain chemicals. Doctors prescribe them as pills, liquids or patches. Healthcare professionals also take medications known as norepinephrine reuptake inhibitors and alpha-2 agonists for treating ADHD. They're usually prescribed "off-label" to treat this condition, since they're FDA-approved for treating