https://www.selleckchem.com/pr....oducts/defactinib.ht
Our simulations indicate that actin subunits at both boundaries adopt structures intermediate between those of bare and cofilin-bound actin subunits. These 'intermediate' states have compromised intersubunit contacts, but the actin subunit interfaces lacking contacts at the slow-severing boundary are stabilized by cofilin bridging interactions, accounting for its lower fragmentation probability. Simulations where cofilin proteins are removed from cofilactin filaments favor a mechanism in which a cluster of two contiguously bound cofi
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