https://www.selleckchem.com/pr....oducts/tiplaxtinin-p
Two mitotic cyclin types, cyclin A and B, exist in higher eukaryotes, but their specialised functions in mitosis are incompletely understood. Using degron tags for rapid inducible protein removal, we analyse how acute depletion of these proteins affects mitosis. Loss of cyclin A in G2-phase prevents mitotic entry. Cells lacking cyclin B can enter mitosis and phosphorylate most mitotic proteins, because of parallel PP2AB55 phosphatase inactivation by Greatwall kinase. The final barrier to mitotic establishment corresponds to
Like
Comment
Share
