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Cognition arises from the dynamic flow of neural activity through the brain. To capture these dynamics, we used mesoscale calcium imaging to record neural activity across the dorsal cortex of awake mice. We found that the large majority of variance in cortex-wide activity (∼75%) could be explained by a limited set of ∼14 "motifs" of neural activity. Each motif captured a unique spatiotemporal pattern of neural activity across the cortex. These motifs generalized across animals and were seen in multiple behavioral environments. Motif exp

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