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ADHD OTC Medication Most adults and children who are taking ADHD medication will experience a few adverse effects. These usually include loss of appetite or stomach upset, as well as changes in heart rate. Healthy eating and enough sleep can reduce these side effects. Stimulant medications boost signaling between brain cells, which helps children to focus and control their impulses. However, they can cause tics and raise blood pressure. are controlled substances and can be crushed or snorted in order to create illegal substances. Methylphenidate Methylphenidate i