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ACE2 counteracts the damaging aftereffects of ACE on CNS neurons. SARS-CoV-2 can right access the CNS through the circulation or via cranial nerve I while the olfactory light bulb. Inactivation of ACE2 following binding of SARS-CoV-2 S protein to ACE2-R in situ might blunt ACE2-moderating results upon ACE CNS neurotoxicity and neurodegeneration. Right here, we propose a neurobiological method directly involving SARS-CoV-2 binding to ACE2-R into the etiology of putative Neuro-CoViD-19. V