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51 (1.03, 2.22)). The certainty of this evidence was rated low by GRADE, due to imprecision. There was no evidence of excess harm with graded exercise therapy by either self-rated deterioration or by withdrawing from GET, in comparison to control interventions. More GET participants dropped out of trial follow up in comparison to control interventions. Future research should ascertain the most effective and safest form of graded exercise therapy. There was no evidence of excess harm with graded exercise therapy by either self-rated dete

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