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The index SNP of 1p21 is an eQTL (P =1.74×10 ) for involved in SUMOlation and is associated with platelet distribution width (1.15×10 ) and 18-carbon fatty acid metabolism (P=7.36×10 ). In gene-based analysis we identified three genes ( , ) at P2.7×10 . 11 of 32 candidate gene loci studied in Indians replicated (P0.05), and 21 of 32 loci identified through previous GWAS replicated based on directionality of effect. This first GWAS of stroke in Indians identified novel loci and replicated previously known loci. For the first tim
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