https://rorreceptor.com/index.....php/susceptibility-o
We reveal that estrogen induces obtainable chromatin and ER binding at a subset of enhancers, which form higher-order extremely enhancers being important for ER signaling. ER positively correlates with energetic enhancers in major tumors, and tumors had been efficiently classified into molecular subtypes with chromatin ease of access characteristics and ER-dependent gene trademark. ARID1A binds within ER-bound enhancers and regulates ER-dependent transcription. Knockdown of ARID1A or
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