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The double-branching rate reflects the particular structure of pairwise selection interactions of the coupled Wright-Fisher diffusion. Moreover, in the special case of two loci, two alleles, with selection and parent independent mutation, the stationary density for the coupled Wright-Fisher diffusion and the transition rates of the dual process are obtained in an explicit form.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to the outbreak of coronavirus disease 2019 (COVID-19), a worldwide epidemic dise