https://www.selleckchem.com/products/msc-4381.html
To develop recombinant factor IX (FIX) variants with augmented clotting activity. We generated three new variants, FIX-YKALW, FIX-ALL and FIX-LLW, expressed in SK-Hep-1 cells and characterized in vitro and in vivo. FIX-YKALW showed the highest antigen expression level among the variants (2.17µg ), followed by FIX-LLW (1.5µg ) and FIX-ALL (0.9µg ). The expression level of FIX variants was two-fivefold lower than FIX-wild-type (FIX-WT) (4.37µg ). However, the biological activities of FIX variants were 15-31 times greater than FIX-WT in t
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