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Based on the results, a mechanism was proposed in which the thermodynamics and kinetics of the TcmN conformational equilibrium modulate enzyme function by favoring ligand binding and avoiding aggregation. Understanding the principles underlying TcmN stability and dynamics may help in designing mutants with optimal properties for biotechnological applications. Understanding the principles underlying TcmN stability and dynamics may help in designing mutants with optimal properties for biotechnological applications. The purpose of

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