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gesting new elements of the genotype-phenotype correlations. Hypoxia is a prominent feature of solid cancer. This research aims to expose the role of mitochondrial creatine kinase 1 (CKMT1) in non-small cell lung cancer (NSCLC) progression and hypoxia adaptation. The mRNA and protein expression of CKMT1 in NSCLC tissues were detected byusing GEPIA web, immunohistochemistry and qRT-PCR. For hypoxia, cells were exposed to the 1% O atmosphere. The protein levels of HIF-1α and CKMT1 in H1650 and H1299 cells exposed to hypoxia were determined
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