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The DES-14 NS1 protein mutant bearing a lysine at position 324 ended up being deficient in protein security and secretion when compared with wild-type necessary protein. The defect into the DES-14 NS1 protein mutant ended up being associated to oxidative stress and pro-inflammatory cytokine activation in Huh7 cells. The ubiquitin-proteasome proteolytic path might play an integral role into the stability of DENV-2 necessary protein bearing a lysine residue at position 324.The
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