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Hemodialysis (HD) is involving intellectual impairment in patients with end-stage renal illness (ESRD). But, the neural method of spatial working memory (SWM) disability in HD-ESRD patients continues to be ambiguous. We investigated the abnormal changes in SWM-associated brain activity patterns in HD-ESRD clients using blood oxygen level-dependent practical magnetic resonance imaging (BOLD-fMRI) strategy during n-back jobs. Twenty-two HD-ESRD customers and 22 well-matched controls