https://www.selleckchem.com/products/bi-3406.html
To evaluate the role of diltiazem on tacrolimus sparing in pediatric primary nephrotic syndrome (PNS) and its relation to CYP3A4, CYP3A5, ABCB1, and SLCO1B3 polymorphisms. The PNS children treated with tacrolimus and with steady-state trough concentration (C ) were retrospectively collected. The impacts of diltiazem on tacrolimus dose-adjusted C (C /D), target concentration achievement, and required dose were evaluated. Meanwhile, the relationship between the polymorphisms (including CYP3A4*1G, CYP3A5*3, ABCB1-C3435T, and SCLO1B3) and d
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