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Objectives Peripheral nerves are commonly damaged. Although the nerve autograft still subsists the gold standard in surgery of nerve injury gaps, it has severe detriment. The egg shell membrane (ESM) is a natural material, which has a great potential in practice. The aim of this survey was to appraise the effect of lycopene and the ESM nerve guidance channel on sciatic nerve regeneration. Materials and methods In this study, 32 male rats were randomized into four groups sham surgery, autograft, ESM+ dimethyl sulfoxide (DMSO), and ESM+lyco
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