https://www.selleckchem.com/
The entry/fusion complex (EFC) consists of eleven conserved proteins embedded in the membrane envelope of mature poxvirus particles. Poxviruses also encode proteins that localize in cell membranes and negatively regulate superinfection and syncytium formation. The vaccinia virus (VACV) A56/K2 fusion regulatory complex associates with the G9/A16 EFC subcomplex, but functional support for the importance of this interaction was lacking. Here we describe serially passaging VACV in non-permissive cells expressing A56/K2 as an unbiased approach to isolate and ana
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