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AT. This new method can be of great importance to the design of circular-scanning or spherical-scanning-based PAT systems. To show that intrinsic radiosensitivity varies greatly for protons and carbon (C) ions in addition to photons, and that DNA repair capacity remains important in governing this variability. We measured or obtained from the literature clonogenic survival data for a number of human cancer cell lines exposed to photons, protons (9.9keV/μm), and C-ions (13.3-77.1keV/μm). We characterized their intrinsic radiosensitivity by

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