https://gsk2334470inhibitor.co....m/augmentative-as-we
Herein, we report a scaffold hybrid strategy of Tanshinone I for the discovery of NLRP3 inflammasome inhibitors. 36 compounds were created and synthesized, in addition to cheminformatic analyses showed that these substances occupy a unique substance space. The biological assessment identified compounds 5j, 12a, and 12d as NLRP3 inflammasome inhibitors with significant effectiveness, selectivity, and drug-likeness. Mechanistic studies unveiled why these Tanshinone I derivatives could prevent the
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