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Nonetheless, we pointed out that there was a broad inter-individual difference in the effectiveness and toxicity of atorvastatin. This study aimed to learn the consequences of major genetic variations in 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR), Apolipoprotein E (APOE), and Solute Carrier natural Anion (SLCO1B1) genes in atorvastatin response among DM2 customers. A sample of 139 DM2 clients on 20 mg of atorvastatin ended up being included in this study. The lipid and glyce