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Exposing the cells to plasma from rats that were afflicted by intracranial self-stimulation (ICSS) markedly upregulated neurite outgrowth. In inclusion, voluntary operating in a wheel or required on a rotating rod was made use of to induce behavioral excitation in rats, and examinations of the plasma confirmed that the ICSS-induced neurite outgrowth wasn't linked to the ICSS behavior it self. Also, immunoblotting and treatment with U0126, an ERK (extracellular signal-regulat

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