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SAR researches for PDE5 inhibition revealed an essential role for a carboxylic acid functionality during the 1-phenyl as well as the need for the non-planar pyrazoline core throughout the planar pyrazole with the 5-phenyl moiety tolerating a range of substituents. These changes resulted in brand new PDE5 inhibitors with approximately 20-fold enhanced potency to restrict PDE5 with no COX-2 inhibitory activity in contrast to celecoxib. PDE isozyme profiling of element 11 disc
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