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5). This set of new insights make this dye useful as a potential "off-on-off" pH-responsive fluorescent probe for biological applications. A pyranoxanthylium dye was developed and revealed a selective fluorescence emission between 5  less then  pH  less then  9, being maximum at pH 7.5, which make it very interesting as a pH-responsive "off-on-off" fluorescent probe for biomedical applications.A novel amphiphilic photosensitizing agent based on a tricationic fullerene C60 (DMC603+) was efficiently synthesized from its non-charged analog

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