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30 log ng/mg creatinine in patients with functional severe glaucoma (visual field mean deviation ≤ -6 d compared with mild glaucoma (mean deviation -6 dB; P = 0.04 and lower UME by 0.05 log ng/mg creatinine with each 10 μm thinning of the circumpapillary retinal nerve fiber layer thickness as the index of structural severity of glaucoma (P = 0.011). In conclusion, significant association between glaucoma and lower urinary 6-sulfatoxymelatonin was found. In addition, patients with functional and structural severe glaucoma were
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