https://www.selleckchem.com/pr....oducts/2-Methoxyestr
Overall, these findings highlight autophagy-dependent control of NBR1 as a key determinant of metastatic progression. Premature loss of sister chromatid cohesion at metaphase is a diagnostic marker for different cohesinopathies. Here, we report that metaphase spreads of many cancer cell lines also show premature loss of sister chromatid cohesion. Cohesion loss occurs independently of mutations in cohesion factors including SA2, a cohesin subunit frequently inactivated in cancer. In untransformed cells, induction of DNA
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