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Great predictability ended up being achieved for thickness, relatively best for yield, dampness content, surface polarity and yield whereas theophylline content and particle size had been defectively predicted. Powders with up to 60per cent theophylline provided spherical (3.7 µm) and thin sized distribution particles, with a high thickness (1.6 g/cm-3) in large yields (70%), steady for 6 month (25 °C/65%RH) in a closed container as well as not any longer than 2
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