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The study cohort included 2702 RRMS patients. The PS matching procedure produced 363 pairs, followed for a median (interquartile range) of 8.5 (6.5-11.7) years. Mean annual delta-EDSS values were all significantly ( 0.02) higher in the ESC group compared with the EIT group. In particular, the mean delta-EDSS differences between the two groups tended to increase from 0.1 (0.01-0.19, = 0.03) at 1 year to 0.30 (0.07-0.53, = 0.009) at 5 years and to 0.67 (0.31-1.03, = 0.0003) at 10 years. Our results indicate that EIT strategy is mo