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This review summarizes recent advances in the understanding of defective but at low level rebalanced hemostasis in stable cirrhosis, discusses clinical consequences and persistent controversial issues related to the inherent bleeding risk, and is focused on a risk-adapted management of thrombocytopenia in patients with chronic liver disease, including a restrictive transfusion regimen.Antibiotic resistance is a public health threat of the utmost importance, especially when it comes to children according to WHO data, infections caused by multidrug resistant