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To compare the efficacy and safety of the hourly administration of titrated oral misoprostol solution (OMS) and vaginal dinoprostone for induction of labor. Titrated OMS was administrated hourly for induction of labor, starting with a dose of 20µg and terminating at a dose of 50µg. The safety and efficacy of OMS were compared with that of vaginal dinoprostone for induction of labor. From June 2016 to October 2019, 2280 (78.3%) and 2115 (72.9%) women who received titrated OMS and vaginal dinoprostone, respectively, had a vaginal delivery (