https://www.selleckchem.com/pr....oducts/CP-690550.htm
Thus, denervation can increase lipid raft formation and attenuate HS-induced alterations probably due to decrease of Cer levels in the raft fraction. The effects of denervation could be at least partially caused by the loss of afferentation. The study points to the importance of motor and afferent inputs in control of Cer distribution and thereby stability of lipid rafts in the junctional and extrajunctional membranes of the muscle.The remarkable prevalence of pyrazole scaffolds in a versatile array of bioactive molecules ranging from
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