https://www.selleckchem.com/ALK.html
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the development of multiple cysts in the kidneys. It is often caused by pathogenic mutations in and genes that encode polycystin proteins. Although the molecular mechanisms for cystogenesis are not established, concurrent inactivating germline and somatic mutations in and have been previously observed in renal tubular epithelium (RTE). To further investigate the cellular recessive mechanism of cystogenesis in RTE, we conducted whole-genome DNA sequencing anal
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