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s contributed to this study. Trials which did not use the ITT principle (ES = -0.13; 95%CI -0.26; 0.01), or which were assessed as having inappropriate control of incomplete outcome data tended to underestimate the treatment effect when compared with trials with adequate use of ITT and control of incomplete outcome data (ES = -0.18; 95%CI -0.29; -0.08).Researchers and clinicians should pay attention to these methodological issues since they could provide inaccurate effect estimates. Authors and editors should make sure that intention to
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