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This paper focuses on 6D pose estimation for weakly textured targets from RGB-D images. A 6D pose estimation algorithm (DOPE++) based on a deep neural network for weakly textured objects is proposed to solve the poor real-time pose estimation and low recognition efficiency in the robot grasping process of parts with weak texture. More specifically, we first introduce the depthwise separable convolution operation to lighten the original deep object pose estimation (DOPE) network structure to improve the network operation speed. Second, a