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81 [95%CI 0.71-0.94]) and dsDNA positive SLE (HR 0.78 [95%CI 0.63-0.95]). Women with four or more healthy factors had the lowest SLE risk overall (HR 0.42 [95%CI 0.25-0.70]) and dsDNA positive SLE (HR 0.35 [95%CI 0.17-0.75]) compared to women with less than or equal to one healthy behavior. The PAR% for SLE from adhering to four or more healthy behaviors was 47.7% [95%CI 23.1-66.6]. Nearly half of SLE risk, a disease where significant evidence of genetic involvement has been established, might be reduced with adherence to modifiable hea