https://www.selleckchem.com/pr....oducts/ly2157299.htm
Finally, we demonstrated the capacity of Δ133p53α to restore the antitumor response of senescent T cells isolated from multiple myeloma patients. This study uncovered a broad effect of Δ133p53α isoform in regulating T lymphocyte function. Enhancing fitness and effector functions of senescent T cells by modulation of p53 isoforms could be exploited for future translational research to improve cancer immunotherapy and immunosenescence-related diseases. This study uncovered a broad effect of Δ133p53α isoform in regulating T lymphocyte fu
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