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In 1962, there was a need for new antiarrhythmic drugs other than quinidine and procainamide, the main available antiarrhythmic agents available at that time. From more than 500 compounds synthesized for the research program of new antiarrhythmic agents, disopyramide is the selected agent. The chemical structures of disopyramide have a resemblance to the synthetic muscarinic antagonist, lachesine, which explained its anticholinergic property.Reserpine is an indole alkaloid extracted from Rauwolfia serpentine roots, an Indian climbing shr
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