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CblC removes the upper axial ligand of cobalamin types, developing an intermediate when you look at the path that is subsequently transformed into the active cofactor derivatives. Mutations into the cblC gene cause methylmalonic aciduria and homocystinuria. Right here, we report that nitrosylcobalamin (NOCbl), that was created as an antiproliferative reagent, and it is purported to cause cellular death by virtue of releasing nitric oxide, is extremely volatil
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