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The importance of the immunosuppressive mechanism of IDO by suppressing T-cell function has actually garnered profound curiosity about the development of medical IDO inhibitors. Herein, we established a screening method with cervical HeLa cells to cause IDO appearance using interferon-γ (IFN-γ). After assessment our chemical library, we found that salinomycin potently inhibited IFN-γ-stimulated kynurenine synthesis with IC50 values of 3.36-4.66 μM in both peoples cervical and cancer of the breast cells. Salinomycin lowered the IDO1 and IDO2
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