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This chapter provides a historical account of the competition to clone the individual heparanase gene, defines the intracellular and extracellular purpose of the enzyme, and explores the different mechanisms regulating heparanase phrase and activity in the gene, transcript, and necessary protein level.Heparanase is the main chemical that degrades heparan sulfate (HS) both in physiological (HS turnover) and pathological (tumefaction metastasis, swelling) mobile circumstances, c
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