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OUTCOMES Nine criterion-meeting researches included 244 CRS patients, with diverse results. Eight studies used 16s-ribosomal RNA (16s-rRNA) gene sequencing to assess the sinonasal microbiome and 1 used 16s-rRNA PhyloChip analysis. Seven researches made use of Sino-Nasal Outcome Test scores, 1 used another CRS symptom metric, and 1 utilized dependence on additional procedures/antibiotics because the major clinical result. Three studies declare that baseline abundan

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