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As the population ages, differences in cognitive abilities become more evident. We investigated key genetic and life course influences on cognitive state at age 69 years, building on previous work using the longitudinal Medical Research Council National Survey of Health and Development (the British 1946 birth cohort). Multivariable regressions investigated the association between 4 factors (1) childhood cognition at age 8 years; (2) a Cognitive Reserve Index (CRI) composed of 3 markers (i) educational attainment by age 26 years, (ii) eng
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