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In contrast, a low IRGPI score was associated with cancer and metastasis-related pathways; high and mutation rate; high infiltration of B cells, M0 macrophages, and M2 macrophages; suppressive immunity and more aggressive phenotypes; and less benefit from ICI therapy. IRGPI is a promising biomarker to distinguish the prognosis, the molecular and immune characteristics, and the immune benefit from ICI therapy in HNSCC. IRGPI is a promising biomarker to distinguish the prognosis, the molecular and immune characteristics, and the immune be
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