https://www.selleckchem.com/pr....oducts/hydroxyfasudi
Leptin is an adipokine that signals energy sufficiency. In rodents, leptin deficiency decreases energy expenditure (EE), which is corrected following leptin replacement. In humans, data are mixed regarding leptin-mediated effects on EE. To determine the effects of metreleptin on EE in patients with lipodystrophy. Non-randomized crossover study of 25 patients with lipodystrophy (NIH, 2013-2018). The initiation cohort consisted of 17 patients without prior exposure to metreleptin, studied before and after 14 days of metrele
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