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magna. In summary, the present study provides insights into the toxic effects of phenicol antibiotic and SP mixtures on aquatic organisms. Environ Toxicol Chem 2021;001-11. © 2021 SETAC.Hemodialysis catheter (HDC) using a tunneled cuffed catheter (TCC) is a viable option for acute hemodialysis. Vessel injury during catheter insertion can lead to malpositioning of the HDC into the mediastinum. We herewith present two malpositioned HDCs in various clinical settings. For the first case, the HDC was inserted without fluoroscopic guidance,